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Contraindicated (1)pentobarbital will lessen the extent or effect of lumefantrine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with sturdy CYP3A4 inducers can result in lowered serum concentrations and lack of antimalarial efficacypentobarbital will reduce the extent or effect of zolpidem by affecting